Overview
Geodon is the brand name for ziprasidone, an antipsychotic used to treat schizophrenia. It is an atypical (newer) antipsychotic whose structure is different than that of older antipsychotics. Geodon is somewhat similar to the antipsychotics Seroquel, Risperdal, Clozaril, and Zyprexa. Geodon helps block the action of serotonin and dopamine and moderately inhibits reuptake of serotonin and norepinephrine. Unlike most antipsychotics, Geodon is not associated with significant weight gain.

Geodon was FDA approved for schizophrenia in February 2001.

Why is this drug prescribed?
Geodon is used to treat both positive and negative symptoms of schizophrenia. Positive symptoms include hallucinations and delusions, while negative symptoms can include social withdrawal and apathy. Although not FDA approved for bipolar disorder, it is often used to treat mania in adults and children.

Warnings and Precautions
In the past, Geodon was associated with a risk of a heart rhythm irregularity by increasing the QTc interval (on an EKG). Several studies since then have shown that the risk of this is very slight and comparable to the risk from other antipsychotics, but it is a factor that must be considered by doctors and patients. Patients should have an EKG performed before starting Geodon to rule out underlying cardiac problems.

Geodon may impair the ability to drive or concentrate, especially at the beginning of therapy. Patients should not drive until Geodon’s effects are known.

Geodon slightly increases a patient’s risk of seizures, particularly in patients over 65.

For Pregnant or Nursing Mothers: Geodon causes fetal problems in animals, and is likely to do so in pregnant women. It is not known whether Geodon passes into breast milk, but breastfeeding while taking Geodon is not recommended.

Contraindications
Geodon should Not be used for people with the following medical conditions:

1. Taking any medication that affects the QT-interval of the heart rhythm (see examples below).